Phylostratigraphic analysis of tumor and developmental transcriptomes reveals relationship between oncogenesis, phylogenesis and ontogenesis

Joseph X. Zhou, Luis Cisneros, Theo Knijnenburg, Kalliopi Trachana, Paul Davies, Sui Huang (2018). Convergent Science: Physical Oncology. IOP Science.

Ancestral gene regulatory networks drive cancer

K. J. Bussey, L. H. Cisneros, C. H. Linweaver, and P. C. W. Davies, PNAS 2017 114 (24) 6160-6162.


Although cancer is one of the most intensively studied phenomena in biology and occurs in almost all multicellular species (12), an explanation for its existence and properties within the context of evolutionary history has received comparatively little attention. However, it is widely recognized that progress in treatment and prevention depends on a deeper understanding of the biology of cancer (3).

Formal definitions of unbounded evolution and innovation reveal universal mechanisms for open-ended evolution in dynamical systems

A. Adams, H. Zenil, P. C. W. Davies and S. I. Walker, Scientific Reports 7 997 (2017).